I've read that man-rating the Delta IV is something Boeing would like, but NASA has not been enthusiastic about it. I'd like to learn more about why.
The issues with its engine weight and such is about costs. The Delta IV is meant to be simple and cheap. IMHO it is the best "big dumb booster" currently around. I'm pretty fond of the Russian Proton too, which is also relatively cheap and has the best reliability statistics for the last few decades (well, since its been in use for 40 years!).
Here are some figures I looked up a while ago, for LEO payload capacity of superheavy and heavy launchers:
Saturn V 118,000 kg payload  3,440,310 kgf liftoff
N-1    95,000 kg      4,500,000 kgf
Energiya  88,000 kg      3,582,250 kgf
Shuttle  27,500 kg      2,875,000 kgf
Delta IV  25,800 kg       884,000 kgf
Proton   21,000 kg       965,580 kgf
Titan IV  17,780 kg      1,307,380 kgf
Ariane 5  16,000 kg      1,566,000 kgf
Atlas 5  12,500 kg       875,500 kgf
R-7/Soyuz  7,420 kg       422,500 kgf