That's less of a concern with hall-effect ion engines, but there are still lots of problems. Nobody has come close, even by a factor of 1000, to building an 8 ton thrust ion engine like the Russians planned for TMK. That may be impossible.
VASIMR is a cool concept. I worry that it has been talked about it for several decades, so how close are we to a working prototype? How close are we to a finished product that can work in space for years at a time?
I have little faith in fusion. Where is it? After decades of expensive research, still nothing. I think even if fusion ever works, the reactor technology will be too heavy and bulky for space. You can build a very compact fission reactor, and it's technology that exists and is proven. But the direct fusion stuff, just pictures people draw with no scientific or engineering study.
I mean, look at diagrams like this, it's just bull****. Like NASA advanced concepts group bull****. None of the technology works, if it did, the thing would vaporize itself in a microsecond.