Wimps.  :P I go for the all-up testing. Manned Orbital-Docking-EVA-Duration. If the docking fails, the budget penalty is negligable. If nothing else, the astronauts stay happy, and the experience goes up. I have never had a successful unmanned docking, and consider them a waste of good equipment.
To clarify about the docking module safety:Â A failed docking attempt will increase the safety factor by 5% (you always learn something), and a successful attempt raises it by 15%.
Hmm, going straight for manned docking? I've always done unmanned first, partly because it doubles as dummy tests of the capsule before putting my spam in a can. OTOH, it might be worth trying the manned docking first--after all, the computer does that and gets away with it ('course, what
doesn't the damned computer get away with?). Next time I play, I'll try the manned docking first!
Incidentally--a successful docking missions raises the safety by 10%, not 15% (unmanned docking, anyway--manned might yield 15%, which could be another incentive to try manned from the start).